마우스를 이용한 PLA - tetracycline 복합체 코팅 금 나노입자 - 티타니아 나노튜브의 적외선 레이저 유도 약물용출 생체 내 평가
In vivo evaluation of infrared LASER mediated drug release of PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes with mouse
문경숙, 정찬권, 배지명, 오승한,
소속 상세정보
문경숙 ( Mon Kyoung-Sook ) - 원광대학교 치과대학 치과생체재료학교실
정찬권 ( Jeong Chan-Gwoun ) - 원광대학교 창의공과대학 전자공학과
배지명 ( Bae Ji-Myung ) - 원광대학교 치과대학 치과생체재료학교실
오승한 ( Oh Seung-Han ) - 원광대학교 치과대학 치과생체재료학교실
KMID : 1035320170440010033
Abstract
In this study, we prepared PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes and estimated their infrared LASER mediated drug release in the abdominal region of ICR mouse. The results of UV-Vis spectrophotometer showed the highest absorbance at the wavelength of 530 nm and 809 nm indicating the existence of gold nanoparticles. EDX analysis showed that the amounts of gold nanoparticle coated on titania nanotubes were approximately 3.62?36.5 wt%. In vivo test resulted that the tetracycline release value of experimental groups (6.5 ng/mL) was higher than that of control group (5.8 ng/mL) on the condition of 30 minutes of LASER irradiation. Therefore, it is expected that PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes have the feasibility in the field of infrared remote controlled drug device and overcome the limitation of location and time of drug release in dental implant.
키워드
PLA-tetracycline complexes; Gold nanoparticle(GNP); Titania nanotubes; Infrared LASER
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